JTE 013 from Tocris Bioscience, a Bio-Techne Brand | Biocompare.com

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JTE 013

S1P2 receptor antagonist

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Tocris Bioscience, a Bio-Techne Brand for
JTE 013

Description

S1P2 receptor antagonist

Product Specs
ItemJTE 013
CompanyTocris Bioscience, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog Number2392/10
Quantity10 mg
Brand/TrademarkTocris, a Bio-Techne Brand
Purity0.98
Molecular Weight408.29
Molecule Name1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide
FormulaC₁₇H₁₉N₇OCl₂
StorageStore at +4°C

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2PloS oneJanuary 1, 2018Matsushima-Nishiwaki R, Yamada N, Fukuchi K, Kozawa O.

(2) Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cellsBiochemical pharmacologySeptember 1, 2016Wirrig C, McKean JS, Wilson HM, Nixon GF.

(3) Nogo-A controls structural plasticity at dendritic spines by rapidly modulating actin dynamicsHippocampusJune 1, 2016Kellner Y, Fricke S, Kramer S, Iobbi C, Wierenga CJ, Schwab ME, Korte M, Zagrebelsky M.

(4) Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2Mediators of inflammationJanuary 1, 2016Chumanevich A, Wedman P, Oskeritzian CA.

(5) Pericyte chemomechanics and the angiogenic switch: insights into the pathogenesis of proliferative diabetic retinopathy?Investigative ophthalmology & visual scienceJune 1, 2015Durham JT, Dulmovits BM, Cronk SM, Sheets AR, Herman IM.

(6) Defective apical extrusion signaling contributes to aggressive tumor hallmarkseLifeJanuary 26, 2015Gu Y, Shea J, Slattum G, Firpo MA, Alexander M, Mulvihill SJ, Golubovskaya VM, Rosenblatt J.

(7) Sphingosine 1-phosphate (S1P) promotes mitochondrial biogenesis in Hep G2 cells by activating Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α)Cell stress & chaperonesJuly 1, 2014Shen Z, Liu C, Liu P, Zhao J, Xu W.

(8) Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cellsPloS oneJanuary 1, 2014Fernández-Pisonero I, López J, Onecha E, Dueñas AI, Maeso P, Crespo MS, San Román JA, García-Rodríguez C.

(9) Sphingosine 1-phosphate counteracts the effects of interleukin-1β in human chondrocytesArthritis and rheumatismAugust 1, 2013Stradner MH, Gruber G, Angerer H, Huber V, Setznagl D, Kremser ML, Moazedi-Fürst FC, Windhager R, Graninger WB.

(10) Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signalingOncogenesisJune 3, 2013Beckham TH, Cheng JC, Lu P, Shao Y, Troyer D, Lance R, Marrison ST, Norris JS, Liu X.

(11) Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathwaysThe Journal of biological chemistryFebruary 22, 2013Quint P, Ruan M, Pederson L, Kassem M, Westendorf JJ, Khosla S, Oursler MJ.

(12) Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signalingPloS oneJanuary 1, 2013Beckham TH, Cheng JC, Lu P, Marrison ST, Norris JS, Liu X.

(13) The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinementNature immunologyJune 5, 2011Green JA, Suzuki K, Cho B, Willison LD, Palmer D, Allen CD, Schmidt TH, Xu Y, Proia RL, Coughlin SR, et al.

(14) Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cellsThe Journal of biological chemistryNovember 12, 2010Long JS, Fujiwara Y, Edwards J, Tannahill CL, Tigyi G, Pyne S, Pyne NJ.

(15) Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venulesAmerican journal of physiology. Heart and circulatory physiologyNovember 1, 2010Zhang G, Xu S, Qian Y, He P.

(16) S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphateAmerican journal of physiology. Lung cellular and molecular physiologyJuly 1, 2010Szczepaniak WS, Pitt BR, McVerry BJ.

(17) Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosisCardiovascular researchJanuary 1, 2010Frias MA, Lang U, Gerber-Wicht C, James RW.

(18) S1P/S1P2 signaling induces cyclooxygenase-2 expression in Wilms tumorThe Journal of urologyMarch 1, 2009Li MH, Sanchez T, Milne GL, Morrow JD, Hla T, Ferrer F.

(19) Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2Molecular cancer research : MCROctober 1, 2008Li MH, Sanchez T, Pappalardo A, Lynch KR, Hla T, Ferrer F.

(20) Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cellsMolecular and cellular biologyJune 1, 2008Miller AV, Alvarez SE, Spiegel S, Lebman DA.

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